|
KMID : 0811720150190030235
|
|
Korean Journal of Physiology & Pharmacology
2015 Volume.19 No. 3 p.235 ~ p.240
|
|
|
Androgen Receptor-dependent Expression of Low-density Lipoprotein Receptor-related Protein 6 is Necessary for Prostate Cancer Cell Proliferation
|
|
Park Eun
Kim Eun-Kyoung
Kim Min-kyoung
Ha Jung-Min
Kim Young-Whan
Jin Seo-Yeon
Shin Hwa-Kyoung
Ha Hong-Koo
Lee Jeong-Zoo
Bae Sun-Sik
|
|
|
Abstract
|
|
|
|
Androgen receptor (AR) signaling is important for prostate cancer (PCa) cell proliferation. Here, we showed that proliferation of hormone-sensitive prostate cancer cells such as LNCaP was significantly enhanced by testosterone stimulation whereas hormone-insensitive prostate cancer cells such as PC3 and VCaP did not respond to testosterone stimulation. Blocking of AR using bicalutamide abolished testosterone-induced proliferation of LNCaP cells. In addition, knockdown of AR blocked testosterone-induced proliferation of LNCaP cells. Basal expression of low-density lipoprotein receptor-related protein 6 (LRP6) was elevated in VCaP cells whereas stimulation of testosterone did not affect the expression of LRP6. However, expression of LRP6 in LNCaP cells was increased by testosterone stimulation. In addition, knockdown of LRP6 abrogated testosterone-induced proliferation of LNCaP cells. Given these results, we suggest that androgen-dependent expression of LRP6 plays a crucial role in hormone-sensitive prostate cancer cell proliferation.
|
|
|
KEYWORD
|
|
|
Androgen receptor, LRP6, Prostate cancer, Testosterone, Wnt
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|